The earliest deed I've seen referencing "Little River" is 1716. Thus far, the earliest non-deed reference I can find for the area using the name Little River is 1734. In that same reference, A New Voyage to Georgia by a Young Gentleman, 1st edition published in 1735. In that account the author references several times stopping at "Ash's, Little River". A 1740 account of Rev. George Whitfield also references both Ash's and Little River.
Below is the most popular account of Pirate activity.
Pirates - Little River is said to have been visited by the likes of William Kidd "Captain Kidd", Edward Teach "Blackbeard", Stede Bonnet and Anne Bonney. Sections of the coast that are laced with islands and inlets were often hideouts of pirates and others who sought concealment and secrecy. There have long been rumors among the locals of buried pirate treasure in the area
Indian settlers of this area called Little River Mineola. Some of the early property owners in the Little River area, reportedly from the late 1600s to the early 1700s - Landgrave Thomas Smith, William Waites (Indian Trader), Thomas Ash, Jonathan Calkins, Boriah Grant, Nicholas Frink, Charles Hart, George Pawley, James Minor, John Bessent, and John Morrall.
Again, I am grateful for anything else you can help me with.